| RQP74134 | |
| I. Background | |
| Interleukin 12 (IL-12) family is unique in having the only heterodimeric cytokines, including IL-12, IL-23, IL-27 and IL-35. The heterodimeric cytokines of the IL-12 family consist of an α-chain (p19, p28 or p35) and a β-chain (p40 or Ebi3). | |
| II. Introduction | |
| Expressed gene: | IL12R |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | CLMF, CLMF2, IL-12B, NKSF, NKSF2, p40, Il-12b, Il12p40, Il-12p40, Il12, IL-12p40, IL-12, LOC100217488, IL-12p35, Il-12a, Ll12a, p35, IL12p40, IL12B, IL-12 p35, interleukin 12B, interleukin 12A, interleukin 12b, interleukin 12a, Interleukin 12 level, IL12B, IL12A, Il12b, Il12a, IL12, il12a |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM +10%FBS+2ug/ml puromycin+200ug/ml hygromycin+5ug/ml blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Representative Data | |
Figure 1. Dose Response of Recombinant Human IL12 in Human IL12 Effector Reporter Cells (C2). | |
Figure 2. Inhibition of IL12-induced Reporter Activity by IL-12/IL -23 p40 Neutralizing Antibody in IL12 Effector Reporter Cells (Clone2). | |
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