| RQP74130 | |
| I. Background | |
| IL-23 is a member of the IL-12 cytokine family, which also includes members such as IL-12, IL-27, IL-35 and IL-39, which are a unique set of heterodimeric cytokines, It usually consists of an alpha chain subunit (p19, p28, or p35) and a beta chain subunit (p40 or Epstein-Barr virus-induced gene 3), and signals are transduced through the JAK/STAT pathway. | |
| II.Introduction | |
| Expressed gene: | IL23R |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | IL-23 Receptor protein, IL-23R protein;Interleukin-23 receptor, IL23R, IL-23 receptor, IL-23R |
| Freeze Medium: | 90% FBS+10%DMSO |
| Culture Medium: | DMEM +10%FBS+2ug/ml puromycin+200ug/ml hygromycin+5ug/ml blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Representative Data | |
Figure 1. Recombinant IL23 Effector Reporter Cell stably expressing IL23R.
Figure 2. Recombinant IL23 Effector Reporter Cell stably expressing IL12β1. | |
Figure 3.Dose Response of Recombinant Human IL23 in Human IL23 Effector Reporter Cells (C6).
Figure 4.Inhibition of lL23-induced Reporter Activity by IL23 Neutralizing Antibody in IL23 Effector Reporter Cells (Clone6). | |
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