| RQP74073 | |
| I. Background | |
| CD155, or poliovirus receptor (PVR), has recently emerged as a pro-tumorigenic antigen, overexpressed on GBM and contributing to increased GBM migration and aggressiveness. CD155 has also been established as an immunomodulatory receptor, able to both activate NK cells through interactions with CD226 (DNAM-1) and CD96 and inhibit them through interaction with TIGIT. | |
| II. Description | |
Recombinant CHO-K1 cells constitutively expressing human CD155 (Poliovirus receptor, Nectin-like protein 5, GenBank accession # NM_006505) and an engineered T cell receptor (TCR) activator. | |
| III. Introduction | |
| Host Cell: | CHO |
| Expressed gene: | CD155 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | Poliovirus receptor, Nectin-like protein 5, CD155-His |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+800ug/ml hygromycin+1ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| IV. Description of Host Cell Line | |
| Organism: | Cricetulus griseus, hamster, Chinese |
| Tissue: | Ovary |
| Disease: | Hamster Chinese ovary |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| Ⅴ. Representative Data | |
Figure 1.Recombinant CHO-cells constitutively expressing CD155 and an engineered T cell receptor (TCR) activator. | |
Figure 2. Dose response of anti-TIGIT neutralizing antibody in TIGIT /NFAT-Reporter Jurkat cell line (C26) with CD155/ TCR activator - CHO. | |
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