| RQP74047 | |
| I. Background | |
| HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα(lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Alternately, interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry. | |
| II. Description | |
| Recombinant HEK293 stably expressing human HVEM (Herpesvirus entry mediator; CD270; TNFRSF14; ATAR) GenBank Accession # NM_003820). | |
| III. Introduction | |
| Host Cell: | HEK293 |
| Expressed gene: | HVEM |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | Immunotherapy, CD270, Herpesvirus entry mediator, HVEM, HEK293, HVEM - HEK293, TNFRSF14, BTLA |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+1ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Description of Host Cell Line | |
| Organism: | Homo sapiens,human |
| Tissue: | Embryonic kidney |
| Disease: | Normal |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| Ⅴ. Representative Data | |
| |
Figure 1.Recombinant HEK293 stably expressing human HVEM (Herpesvirus entry mediator; CD270; TNFRSF14; ATAR) GenBank Accession # NM_003820). | |
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