| RQPB0002 | |
| I. Background | |
| The STAT3 Reporter (Luc)-HEK293 cell line is designed for monitoring STAT3 signal transduction pathway. It contains a firefly luciferase gene driven by STAT3 response elements located upstream of the minimal TATA promoter. | |
| II. Description | |
| After activation by cytokines and growth factors, endogenous STAT3 binds to the DNA response elements, inducing transcription of the luciferase reporter gene. | |
| III. Introduction | |
| Host Cell: | HEK293 |
| Expressed gene: | STAT3-Luciferase |
| Stability: | 32 passages |
| Synonym(s): | Acute-Phase Response Factor, DNA-Binding Protein APRF, DNA, ADMIO, Signal Transducer And Activator Of Transcription 3, TATA |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| IV. Description of Host Cell Line | |
| Organism: | Homo sapiens, human |
| Tissue: | Embryonic kidney |
| Disease: | Normal |
| Morphology: | Epitheloid |
| Growth Properties: | Adherent |
| Ⅴ. Representative Data | |
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Figure 1. Inhibition of IL-6-induced Reporter Activity by IL-6 Neutralizing Antibody in STAT3 (Luc) Reporter HEK293 Cells. | |
Figure 2. STAT3 Luciferase Reporter-HEK293 Cells (C7). | |
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