MDM2 Loss Reference Standard | |
Format | Genomic DNA |
Description | MDM2, MDM2 proto-oncogene, is an E3 ubiquitin protein ligase that mediates Tp53 degradation and therefore, regulates apoptosis and cell-cycle (PMID: 27993876). Amplification and/or overexpression of MDM2 has been identified in several cancer types (PMID: 23303139, PMID: 31440117) and amplification is common in liposarcoma (PMID: 30237864) and has been observed with Mdm2 overexpression in anaplastic lymphoma kinase (ALK)-negative inflammatory myofibroblastic tumors (PMID: 32195970). |
Technical Data | |
Copy number | 1 |
Definition | Loss |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purity | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | Download for COA |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |