RQP20183R | |
| Format | RNA |
| Description | FGFR2, fibroblast growth factor receptor 2, is a receptor tyrosine kinase activated upon binding of the FGF ligand, which activates RAS-MAPK and PI3K-AKT pathways (PMID: 22508544). Altered function of FGFR2 through activating mutations, fusions, and amplification increases cell proliferation and tumorigenesis (PMID: 22508544) and is observed in prostate (PMID: 30761180), breast, lung, uterine, and ovarian cancers (PMID: 29104507), while FGFR2 amplification (PMID: 31076567) and overexpression (PMID: 30662521) is commonly observed in gastric cancer. |
| Technical Data | |
| Left Gene | FGFR2 |
| Left Breakpoint | chr10:123243212:- |
| Right Gene | AHCYL1 |
| Right Breakpoint | chr1:110551656:+ |
| Cosmic ID | N/A |
| Buffer | RNase-free H2O |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purity | Download for COA |
| RNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | -80℃ |
| Expiry | 12 months from the date of manufacture |
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