RQP10401 | |
| Format | Genomic DNA |
| Description | The L861Q mutation results in an amino acid substitution at position 861 in EGFR, from a leucine (L) to a glutamine (Q). This mutation occurs within exon 21, which encodes part of the kinase domain, and occurs with a frequency of approximately 2% in EGFR-mutated lung tumors (Mitsudomi and Yatabe 2010). This mutation is associated with increased sensitivity to the EGFR TKIs, erlotinib (Tarceva) and gefitinib (Iressa; Lynch et al. 2004). |
| Technical Data | |
| DNA Change | c.2582T>A |
| AA Change | p.L861Q |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000275493 |
| Cosmic ID | COSM6213 |
| Chr position(GRCh37) | chr7:55259524 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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