RQP10474 | |
| Gene | ERBB2 |
| Description | ERBB2 (HER2), erb-b2 receptor tyrosine kinase 2, is an EGFR receptor tyrosine kinase that activates PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways, therefore regulating growth and transformation (PMID: 17471238). ERBB2 (HER2) amplification, overexpression, and activation has been implicated in several tumor types (PMID: 17471238). |
| Technical Data | |
| DNA Change | c.2331_2332insTGTGGG |
| AA Change | p.V777_G778insCG |
| Mutation type | In_Frame_Ins |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | NM_004448.3 |
| Cosmic ID | N/A |
| Chr position(GRCh37) | chr17:37881002_37881003 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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