RQP10433 | |
| Gene | ERBB2 |
| Description | ERBB2 (HER2) V777L lies within the protein kinase domain of the Erbb2 (Her2) protein (UniProt.org). V777L results in increased Erbb2 (Her2) activity, increased downstream Mapk pathway activation, increased ability to transform cells in culture (PMID: 29967253), and increased tumor growth in xenograft models (PMID: 23220880) |
| Technical Data | |
| DNA Change | c.2329G>T |
| AA Change | p.V777L |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | NM_004448.3 |
| Cosmic ID | COSM14062 |
| Chr position(GRCh37) | chr17:37881000 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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