CYP1A1 gene polymorphism drug guide standard

Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein, encoded in humans by the CYP1A1 gene, which is a member of the cytochrome P450 enzyme superfamily. CYP1A1 is also known as AHH (aryl hydrocarbon hydroxylase). It participates in the metabolic activation of aromatic hydrocarbons (polycyclic aromatic hydrocarbons, PAHs) by converting benzo[a]pyrene (BaP) to epoxides. In this reaction, the oxidation of benzo[a]pyrene is catalyzed by CYP1A1 to form BaP-7,8-epoxide, which can be further oxidized by epoxide hydrolase (EH) to form BaP-7,8-dihydro diol. Finally, CYP1A1 catalyzes this intermediate to form BaP-7,8-dihydrodiol-9,10-epoxide, which is a carcinogen.

The CYP1A subfamily includes CYP1A1 and CYP1A2. In the extrahepatic metabolism of exogenous substances, CYP1A1 accounts for 2.5%, and is mainly involved in the metabolism of exogenous substances polycyclic aromatic hydrocarbons. Under certain circumstances, exogenous substances combine with the aromatic hydrocarbon receptor (AHR) in the body to induce abnormal expression of CYP1A1; lead to the formation of adducts between highly active substances and DNA or proteins, thereby inducing gene mutations and affecting the human body. various physiological processes. CYP1A2 is specifically expressed in the liver and is one of the important liver P450 monooxygenases. It participates in the transformation and metabolism of most carcinogens and endogenous substances in life, and also participates in the metabolism of about 10% of drugs in clinical practice. Implications for pharmacology and toxicology.

With the continuous development of genetic testing technology, the screening and detection of SNP is faster and more convenient, and SNP is of great significance for the diagnosis of etiology and guiding treatment. At present, the research hotspots on CYP1A1 gene polymorphism sites at home and abroad mainly focus on three sites: CYP1A1*2A 3801T→C ( rs4646903 ), CYP1A1 5423G→A ( rs4646422 ), and CYP1A1*2C 2445A→G ( rs1048943 ).

The detection of CYP1A1 gene is of great significance to clinical patients. In order to ensure the accuracy of gene detection, we have launched standard products related to drug-guided gene detection, which can be selected by manufacturers of kit development.

CYP1A1*5 Reference Standard RQPA0029

CYP1A1*2C Reference Standard RQPA0030