| RQP73324 | |
| I. Introduction | |
Cell Line Name： | EZR-ROS1/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
| EZR, ezrin, is a member of the ERM family that links the cytoplasm to the actin cytoskeleton and regulates polarization and migration in leukocytes and macrophages. EZR plays a role in metastasis in a number of cancer types although decreased Ezr expression has been associated with decreased survival in clear cell renal carcinoma and an EZR-ROS1 fusion has been identified in lung cancer. | |
| III. Representative Data | |
1.Sanger of EZR-ROS1/BaF3
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2. Anti-proliferation assay
Figure 2. CTG Proliferation Assay of BaF3 EZR-ROS1 (C5). | |
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