c-Kit V559A/BaF3

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Detailed introduction

RQP73286
I. Introduction
Cell Line Name：	c-Kit V559A/BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application:	Anti-proliferation assay and PD assay
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS
Mycoplasma Status:	Negative

II.Background
KIT V559A lies within the juxtamembrane domain (exon 11) of the Kit protein (PMID: 15837988). V559A results in constitutive phosphorylation of Kit and increased Mapk and Akt activation in patient samples and cultured cells (PMID: 15837988, PMID: 19047099).

III. Representative Data
1.Sanger of c-Kit V559A/BaF3
2. Anti-proliferation assay

Figure 3. CTG Proliferation Assay of BaF3 c-KIT V559A (C2).