| CBP73215 | |
| I. Introduction | |
Cell Line Name： | CCDC6-RET [V804L]/BaF3 |
Host Cell: | BA/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS+1ug/ml puromycin |
Mycoplasma Status: | Negative |
| II.Background | |
CCDC6, coiled-coil domain containing 6, has been shown to play a role in the DNA damaging signaling pathway acting as a substrate of ATM (PMID: 17420723). CCDC6 fusions with RET (PMID: 23154560, PMID: 26078337) and BRAF (PMID: 26314551) have been observed in multiple cancer types. | |
| III. Representative Data | |
1.WB of CCDC6-RET V804L/BaF3
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2. Sanger of CCDC6-RET [V804L]/BaF3 | |
Figure 2. Breakpoint of CCDC6-RET V804L/BaF3 | |
Figure 3. Point mutation of CCDC6-RET V804L/BaF3 | |
| 3. Anti-proliferation assay | |
Figure 4. Anti-proliferation assay of one reference compounds on the CCDC6-RET V804L/BaF3 Stable Cell Line. | |
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