Cell Line Name：

CCDC6-RET WT/BaF3

Host Cell:

BA/F3

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS+1ug/ml puromycin

Mycoplasma Status:

Negative

CCDC6, coiled-coil domain containing 6, has been shown to play a role in the DNA damaging signaling pathway acting as a substrate of ATM (PMID: 17420723). CCDC6 fusions with RET (PMID: 23154560, PMID: 26078337) and BRAF (PMID: 26314551) have been observed in multiple cancer types.

1. WB of  CCDC6-RET WT/BaF3WT 

2. Sanger of CCDC6-RET WT/BaF3

Figure 2. Breakpoint of CCDC6-RET WT/BaF3

2. Anti-proliferation assay

Figure 3. CTG assay of  for CCDC6-RET WT/BaF3 Stable Cell Line,the Gi50 was 137.3nM.