Cell Line Name：

EGFR D770_N771insG/BaF3

Host Cell:

Ba/F3

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

Complete Culture Medium:

Mycoplasma Status:

Negative

EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity.EGFR D770_N771insG results in the insertion of a glycine (G) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insG has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions.

1. WB of EGFR D770_N771insG/BaF3

2. Anti-proliferation assay