| RQP71410 | |
| I. Background | |
| CXCR1 (C-X-C Motif Chemokine Receptor 1) is a Protein Coding gene.The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. | |
| II. Introduction | |
| Host Cell: | CHO |
| Stability: | 20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | |
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): | Functional assay for CXCR1 receptor |
| Assay Format: | β-arrestin recruitment |
| Ⅲ. Description of Host Cell Line | |
| Organism: | Hamster |
| Tissue: | Ovary |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| Ⅳ. Representative Data | |
Figure 1. Dose response of Human lL8 in CXCR1 β-Arrestin CHO-K1 Cell Line (C17). | |
Figure 2. Inhibition of hlL-8(CXCL8)-induced Beta-Arrestin Recruitment By IL-8 Neutralization Ab in CXCR1 Beta-Arrestin CHO-K1 Cells (C17). | |
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