| RQP71361 | |
| I. Background | |
| Calcitonin receptor‐like (CALCRL) is a G-protein coupled neuropeptide receptor involved in various biological processes such as proliferation, apoptosis, and inflammation. | |
| II. Introduction | |
| Host Cell: | HEK293 |
| Stability: | 20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2ug/ml puromycin+5ug/ml blastcidin |
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Transducer: | Gs |
| Ⅲ. Description of Host Cell Line | |
| Organism: | Human |
| Tissue: | kidney |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| Ⅳ. Representative Data | |
Figure 1. Dose Response of Agonists in Human CALCRL/RAMP1 CRE Luc Reporter HEK293 Cells (C1).
Figure 2. Inhibtion of αCGRP induced Reporter Activity by CGRP Neutralizing Antibodies in CALCRL&RAMP1 CRE Luc HEK293 Cells.
Figure 3. Inhibition of βCGRP induced Reporter Activity by CGRP Neutralizing Antibodies in CALCRL&RAMP1 CRE Luc HEK293 Cells. | |
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